Effects of Statin Treatment on the Development of Tendinopathy: A Nationwide Population-Based Cohort Study

Background: Previous longitudinal cohort studies have reported the conflicting results of relationship between statin use and development tendinopathy disorder. It is unclear if there a use, particularly type or cumulative doses, Purpose: To investigate an association treatment tendinopathy. Study Design: Cohort study; Level evidence, 3. Methods: A total 594,130 participants were enrolled in this study 2002 evaluated until 2015. There 84,102 users 168,204 nonusers (controls) selected at ratio 1:2 using propensity score matching analysis. The types included as follows: (1) trigger finger, (2) radial styloid tenosynovitis, (3) elbow epicondylitis, (4) rotator cuff tendinopathy, (5) Achilles tendinitis. Cox proportional hazards models with time-varying covariates constructed to identify development. Results: Statin treatments regardless associated significantly greater risk all (hazard ratio, 1.435; 95% CI, 1.411-1.460) compared no treatment. trend toward reduction was observed according which indicated by hazard ratios 2.337 (95% 2.269-2.406), 2.210 2.132-2.290), 1.1 1.098-1.146) patients defined daily doses 90, 91-180, >180, respectively. Conclusion: This nationwide population-based suggests that nonusers. diluted increasing dose.